
Ivabradine hydrochloride
CAS No. 148849-67-6
Ivabradine hydrochloride( S 16257 )
Catalog No. M12059 CAS No. 148849-67-6
Ivabradine hydrochloride, a new If inhibitor with IC 50 of 2.9 μM, which is a pure heart rate lowering agent.
Purity : >98% (HPLC)






Size | Price / USD | Stock | Quantity |
25MG | 45 | In Stock |
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50MG | 61 | In Stock |
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100MG | 88 | In Stock |
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200MG | 133 | In Stock |
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500MG | 237 | In Stock |
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1G | Get Quote | In Stock |
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Biological Information
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Product NameIvabradine hydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionIvabradine hydrochloride, a new If inhibitor with IC 50 of 2.9 μM, which is a pure heart rate lowering agent.
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DescriptionIvabradine hydrochloride, a new If inhibitor with IC 50 of 2.9 μM, which is a pure heart rate lowering agent.(In Vitro):Ivabradine hydrochloride (1, 10, 20 mg/kg; i.p.) shows anticonvulsant and neuroprotective action in mice.Ivabradine hydrochloride (5, 10, 20 mg/kg;p.o.; daily for 1 weeks) lowers heart rate in mice with enhanced sympathoadrenergic activities.
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In Vitro——
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In VivoIvabradine hydrochloride (1, 10, 20 mg/kg; i.p.) shows anticonvulsant and neuroprotective action in mice.Ivabradine hydrochloride (5, 10, 20 mg/kg;p.o.; daily for 1 weeks) lowers heart rate in mice with enhanced sympathoadrenergic activities. Animal Model:25-30 g, 6 weeks male Swiss mice Dosage:1, 10, 20 mg/kg Administration:I.p.; for 3 days Result:Attenuated PTZ- and PICRO-induced seizures while presented an antioxidant effect in allbrain areas studied, and reduced cleaved caspase-3 expression in the CA1 and DG region of PICRO- and PTZ-treated mice, respectively.Animal Model:3-4 months transgenic (TG) mice with cardiac-restricted overexpression of b2AR Dosage:5, 10, 20 mg/kg Administration:P.o; daily for 1 weeks Result:Reduced the maximal HR increase in response to the b-agonist isoproterenol, without modifying the response of contractile parameters at 10 mg/kg.
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SynonymsS 16257
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PathwayEndocrinology/Hormones
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TargetAdrenergic Receptor
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RecptorAdrenergic Receptor
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Research AreaCardiovascular Disease
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Indication——
Chemical Information
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CAS Number148849-67-6
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Formula Weight505.05
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Molecular FormulaC27H37ClN2O5
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Purity>98% (HPLC)
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SolubilityEthanol: 101 mg/mL (199.98 mM); Water: 82 mg/mL (162.36 mM); DMSO: 101 mg/mL (199.98 mM)
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SMILESCN(CCCN1CCC2=CC(=C(C=C2CC1=O)OC)OC)C[C@H]3CC4=CC(=C(C=C34)OC)OC.Cl
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Chemical Name——
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1.Fang Y, et al. J Cardiovasc Pharmacol, 2012. 59(3): p. 260-7.
molnova catalog



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